Led by Vogue editor in chief Anna Wintour, Fashion’s Night Out started three years ago in response to economic doldrums.

“The idea was to get the economy rolling,” said shoe designer Stuart Weitzman. “Now it’s become one of the giant charity events in America.”

At his Madison Avenue boutique Thursday night, Weitzman stood next to a display of the four shoes he designed with celebrities to raise money for ovarian cancer research.

Michelle Trachtenberg was wearing her contribution to the Young Hollywood Cares Collection, a pair of dark blue snakeskin platforms with studs on the heels.

“They’re perfect for Georgina,” she said, referring to her character on “Gossip Girl.”

Hayden Panettiere had climbed into a green Fendi jumpsuit, with black suede booties from the Cares collection.

“If I were wearing stilettos, I wouldn’t be standing here,” said the actress of “Heroes” and “Scream 4” fame. She’d been on her feet for an hour.

As for getting involved in a project that supports ovarian cancer research -- specifically the lab of Dr. Marsha A. Moses at the Folkman Institute in Boston -- “it makes you feel much better about indulging in guilty pleasures, like shopping,” she said.

The shoes retail for between $425 and $498. In the month of September, which is Ovarian Cancer Awareness Month, 100 percent of that amount will go to Dr. Moses.